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Annexes or Addenda to Guidelines have now been incorporated into the core Guidelines and are indicated as revisions to the core Guideline (e.g., R1).
For implementation reasons, the Regulatory Authorities working within the ICH Regions may not have changed the codification retrospectively.
Because the new system applies to existing as well as new ICH Guidelines a history box has been added to the beginning of all Guidelines to explain how the Guideline was developed and what is the latest version.
With the new codification revisions to an ICH Guideline are shown as (R1), (R2), (R3) depending on the number of revisions.
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